Pharmacogenetics of parkinsonism, rigidity, rest tremor, and bradykinesia in African‐Caribbean inpatients: Differences in association with dopamine and serotonin receptors
Identifieur interne : 000D10 ( Main/Exploration ); précédent : 000D09; suivant : 000D11Pharmacogenetics of parkinsonism, rigidity, rest tremor, and bradykinesia in African‐Caribbean inpatients: Differences in association with dopamine and serotonin receptors
Auteurs : Asmar F. Al Hadithy [Pays-Bas] ; Bob Wilffert [Pays-Bas] ; Roy E. Stewart [Pays-Bas] ; Nicole M. Looman [Pays-Bas] ; Richard Bruggeman [Pays-Bas] ; Jacobus R. Brouwers [Pays-Bas] ; Glenn E. Matroos [Pays-Bas] ; Jim Van Os [Pays-Bas] ; Hans W. Hoek [Pays-Bas] ; Peter N. Van Harten [Pays-Bas]Source :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics [ 1552-4841 ] ; 2008-09-05.
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Abstract
We studied the association between polymorphisms of genes coding for dopamine D2 (DRD2), dopamine D3 (DRD3), serotonin 2a (HTR2A), and serotonin 2c (HTR2C) receptors and Antipsychotic‐Induced Parkinsonism (AIP), rigidity, bradykinesia, and rest‐tremor in African‐Caribbeans treated with antipsychotics. Polymorphisms of DRD2 (‐141CIns/Del, TaqIA, 957C > T), DRD3 (Ser9Gly), HTR2A (‐1438A > G, 102T > C, His452Tyr), and HTR2C (‐759C > T, Cys23Ser) genes were determined according to standard protocols. The Unified Parkinson Disease Rating Scale was used for the measurement of AIP, rigidity, bradykinesia, and rest‐tremor. Chi‐squared or Fisher's exact tests were applied for the association analyses. The t‐test was applied for continuous data. Ninety nine males and 27 females met the inclusion criteria (Schizophr Res 1996, 19:195). In males, but not in females, there were significant associations between ‐141CDel‐allele carriership (DRD2) and rigidity (Fisher's Exact Test: P = 0.021) and between 23Ser‐allele carriership (HTR2C) and bradykinesia (P = 0.026, χ2 = 5.0) or AIP (P = 0.008, χ2 = 7.1). Rest‐tremor was not associated with any of the polymorphisms studied. Analyses of the age, chlorpromazine equivalents, benztropine equivalents, the number of patients using anticholinergic medication, and the utilization patterns of the antipsychotic medication did not show statistically significant differences between patients with and without AIP, rigidity, bradykinesia, rest‐tremor. Conducting the analysis without gender stratification did not affect our findings considerably, except for the association between bradykinesia and 23Ser‐allele which failed to reach statistical significance in the total sample (P = 0.0646, χ2 = 3.41). Since AIPs subsymptoms (rigidity, bradykinesia, and rest‐tremor) may differ pharmacogenetically, our data strongly support symptom‐specific analysis of AIP. However, further research is warranted to confirm our findings. © 2008 Wiley‐Liss, Inc.
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DOI: 10.1002/ajmg.b.30746
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Capriles Clinic, Curaçao, Netherlands Antilles</wicri:regionArea><wicri:noRegion>Netherlands Antilles</wicri:noRegion></affiliation></author><author><name sortKey="Van Os, Jim" sort="Van Os, Jim" uniqKey="Van Os J" first="Jim" last="Van Os">Jim Van Os</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Psychiatry and Neuropsychology, Maastricht University, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Hoek, Hans W" sort="Hoek, Hans W" uniqKey="Hoek H" first="Hans W." last="Hoek">Hans W. 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Genet.</title><idno type="ISSN">1552-4841</idno><idno type="eISSN">1552-485X</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-09-05">2008-09-05</date><biblScope unit="volume">147B</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="890">890</biblScope><biblScope unit="page" to="897">897</biblScope></imprint><idno type="ISSN">1552-4841</idno></series><idno type="istex">A612D56D00F3C90E6E457842FE4373DD4DF93993</idno><idno type="DOI">10.1002/ajmg.b.30746</idno><idno type="ArticleID">AJMG30746</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-4841</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>antipsychotics</term><term>bradykinesia</term><term>parkinsonism</term><term>rigidity</term><term>tremor</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the association between polymorphisms of genes coding for dopamine D2 (DRD2), dopamine D3 (DRD3), serotonin 2a (HTR2A), and serotonin 2c (HTR2C) receptors and Antipsychotic‐Induced Parkinsonism (AIP), rigidity, bradykinesia, and rest‐tremor in African‐Caribbeans treated with antipsychotics. Polymorphisms of DRD2 (‐141CIns/Del, TaqIA, 957C > T), DRD3 (Ser9Gly), HTR2A (‐1438A > G, 102T > C, His452Tyr), and HTR2C (‐759C > T, Cys23Ser) genes were determined according to standard protocols. The Unified Parkinson Disease Rating Scale was used for the measurement of AIP, rigidity, bradykinesia, and rest‐tremor. Chi‐squared or Fisher's exact tests were applied for the association analyses. The t‐test was applied for continuous data. Ninety nine males and 27 females met the inclusion criteria (Schizophr Res 1996, 19:195). In males, but not in females, there were significant associations between ‐141CDel‐allele carriership (DRD2) and rigidity (Fisher's Exact Test: P = 0.021) and between 23Ser‐allele carriership (HTR2C) and bradykinesia (P = 0.026, χ2 = 5.0) or AIP (P = 0.008, χ2 = 7.1). Rest‐tremor was not associated with any of the polymorphisms studied. Analyses of the age, chlorpromazine equivalents, benztropine equivalents, the number of patients using anticholinergic medication, and the utilization patterns of the antipsychotic medication did not show statistically significant differences between patients with and without AIP, rigidity, bradykinesia, rest‐tremor. Conducting the analysis without gender stratification did not affect our findings considerably, except for the association between bradykinesia and 23Ser‐allele which failed to reach statistical significance in the total sample (P = 0.0646, χ2 = 3.41). Since AIPs subsymptoms (rigidity, bradykinesia, and rest‐tremor) may differ pharmacogenetically, our data strongly support symptom‐specific analysis of AIP. However, further research is warranted to confirm our findings. © 2008 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Groningue (province)</li></region><settlement><li>Groningue</li></settlement><orgName><li>Université de Groningue</li></orgName></list><tree><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Al Hadithy, Asmar F" sort="Al Hadithy, Asmar F" uniqKey="Al Hadithy A" first="Asmar F." last="Al Hadithy">Asmar F. Al Hadithy</name></region><name sortKey="Al Hadithy, Asmar F" sort="Al Hadithy, Asmar F" uniqKey="Al Hadithy A" first="Asmar F." last="Al Hadithy">Asmar F. Al Hadithy</name><name sortKey="Al Hadithy, Asmar F" sort="Al Hadithy, Asmar F" uniqKey="Al Hadithy A" first="Asmar F." last="Al Hadithy">Asmar F. Al Hadithy</name><name sortKey="Brouwers, Jacobus R" sort="Brouwers, Jacobus R" uniqKey="Brouwers J" first="Jacobus R." last="Brouwers">Jacobus R. Brouwers</name><name sortKey="Brouwers, Jacobus R" sort="Brouwers, Jacobus R" uniqKey="Brouwers J" first="Jacobus R." last="Brouwers">Jacobus R. Brouwers</name><name sortKey="Bruggeman, Richard" sort="Bruggeman, Richard" uniqKey="Bruggeman R" first="Richard" last="Bruggeman">Richard Bruggeman</name><name sortKey="Bruggeman, Richard" sort="Bruggeman, Richard" uniqKey="Bruggeman R" first="Richard" last="Bruggeman">Richard Bruggeman</name><name sortKey="Hoek, Hans W" sort="Hoek, Hans W" uniqKey="Hoek H" first="Hans W." last="Hoek">Hans W. Hoek</name><name sortKey="Hoek, Hans W" sort="Hoek, Hans W" uniqKey="Hoek H" first="Hans W." last="Hoek">Hans W. Hoek</name><name sortKey="Looman, Nicole M" sort="Looman, Nicole M" uniqKey="Looman N" first="Nicole M." last="Looman">Nicole M. Looman</name><name sortKey="Matroos, Glenn E" sort="Matroos, Glenn E" uniqKey="Matroos G" first="Glenn E." last="Matroos">Glenn E. Matroos</name><name sortKey="Stewart, Roy E" sort="Stewart, Roy E" uniqKey="Stewart R" first="Roy E." last="Stewart">Roy E. Stewart</name><name sortKey="Van Harten, Peter N" sort="Van Harten, Peter N" uniqKey="Van Harten P" first="Peter N." last="Van Harten">Peter N. Van Harten</name><name sortKey="Van Harten, Peter N" sort="Van Harten, Peter N" uniqKey="Van Harten P" first="Peter N." last="Van Harten">Peter N. Van Harten</name><name sortKey="Van Os, Jim" sort="Van Os, Jim" uniqKey="Van Os J" first="Jim" last="Van Os">Jim Van Os</name><name sortKey="Wilffert, Bob" sort="Wilffert, Bob" uniqKey="Wilffert B" first="Bob" last="Wilffert">Bob Wilffert</name><name sortKey="Wilffert, Bob" sort="Wilffert, Bob" uniqKey="Wilffert B" first="Bob" last="Wilffert">Bob Wilffert</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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